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HPV Testing

HPV REPORTING WITH APTIMAR HPV ASSAY

DANGERS OF HPV  Thin-Prep-Group.jpg

HPV infections of the genital tract are the most common sexually transmitted disease in North America, causing elevated risks of cervical cancer for an estimated 125 million people. Physicians Laboratory's HPV test reports combine key information about a patient's health picture with the results of HPV tests performed, using the AptimaR HPV Assay.
In addition, PL will also offer the AptimaR HPV 16, 18/45 genotype assay for women with AptimaR HPV assay positive tests.  HPV type 45 is the third most common HPV type in invasive cervical cancer.  In addition, this type identifies more woment at risk for adenocarcinoma, with minimal impact to colposcopy rates.  See chart below.

The HPV result, along with the cytology report, provides integrated medical information and management considerations.


FEATURES & BENEFITS OF THE APTIMAR HPV ASSAYS 

  • targets E6/E7 messenger RNA (mRNA) 
  • excellent sensitivity and improved specificity as compared to DNA tests
  • Only 1 ml of specimen required
  • FDA approved  

The AptimaR  HPV Assay has some known interferences.  These include personal lubricants (containing Polyquaternium 15) at 0.1% w/v (weight/volume) and anti-fungal cream (containing tioconazole) at 0.3% w/v.  Interferences by personal lubricants and anti-fungal cream should not ordinarily be encountered with proper clearing of the cervix before obtaining cell samples for cytology.

The AptimaR HPV 16 18/45 Genotype Assay has some known interferences.  These include personl lubricants (containing Polyquarternium 15) at 1% w/v, anti-fungal cream (containing tioconazole) at 0.03% w/v, mucus at 0.3% w/v, intravaginal hormones (containing progesterone) at 1% w/v and Trichomonas vaginalis at 3x10cells/ml.  Interference by personal lubricants, anti-fungal cream and mucus should not ordinarily be encountered with proper clearing of the cervix before obtaining cell smaples for cytology.