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Surgical Pathology
Pap Test Collection Guidelines
Thin Prep Imaging System
Gyn Cytology Reporting
Aptima HPV Assays
Aptima Combo 2 CT/NG Testing
Aptima Trich Assay
Testing / Treatment Recommendations
Non Gyn Cytology
Patient FAQs and FACTS
Chlamydia/Gonorrhea Testing

Physicians Laboratory uses the AptimaR Combo 2 assay run on Hologic's Panther system for Chlamydia and Gonorrhea testing.  The AptimaR Combo 2 targets ribosomal RNA (rRNA) which is biologically more abundant than DNA.  This offers increased sensitivity over tests that target DNA.  Studies have shown that the Aptima Combo 2 assay is clinically more sensitive to culture and non-amplified test methods and is the most sensitive nucleic acid amplification test available.

Chlamydia is the most frequently reported infectious disease in the United States with over 3 million new cases estimated annually.

  • Young women ages 15-19 represent 46% of infections; 20- to 24-year old women represent another 33%.
  • Up to 75% of cases are asymptomatic. Untreated chlamydia can cause PID, infertility, and ectopic pregnancy.
  • CDC guidelines call for chlamydia screening at least annually for all sexually active females under 20 years of age and annually for women ages 20 and over with one or more risk factors.
  • The annual cost of chlamydia and its consequences in the U.S. is more than $2 billion.
There are an estimated 800,000 new cases of gonorrhea in the United States per year
The reported gonorrhea rate in the U.S. remains the highest of any industrialized country and is roughly 50 times that of Sweden and 8 times that of Canada.
  • Between 1997 and 1999, U.S. gonorrhea rates increased by 9%.
  • Often asymptomatic in women, gonorrhea can lead to PID and infertility if left untreated.
  • The annual cost of gonorrhea and its complications is estimated at nearly $1.1 billion.

Collection guidelines:

CT/NG testing MUST be ordered at the time of the Pap test.  There are check boxes on the Gyn thin_prep_2.jpgrequisition and one or both may be marked.  The Pap results will be released when all testing is completed.